MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblasts

BACKGROUND: The DNA of rheumatoid arthritis synovial fibroblasts (RASF) is globally hypomethylated; this contributes to an aggressive behaviour. In an attempt to remethylate these cells, we supplemented with methyl donors. We investigated the possible interference of microRNAs (miRs). MATERIAL AND M...

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Bibliographic Details
Published in:RMD Open
Main Authors: Gaur, Niharika, Karouzakis, Emmanuel, Glück, Selene, Bagdonas, Edvardas, Jüngel, Astrid, Michel, Beat A, Gay, Renate E, Gay, Steffen, Frank-Bertoncelj, Mojca, Neidhart, Michel
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2016
Subjects:
Rheumatoid Arthritis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073550/
https://ncbi.nlm.nih.gov/pubmed/27843576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2016-000299
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