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The epigenome of synovial fibroblasts: an underestimated therapeutic target in rheumatoid arthritis

Perturbed epigenetic landscape and deregulated microRNA networks are central to the permanent activation and aggressiveness of synovial fibroblasts in rheumatoid arthritis. Current anti-cytokine therapies, although effectively halting synovitis, cannot reverse the stably activated destructive phenot...

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Detalhes bibliográficos
Main Authors: Frank-Bertoncelj, Mojca, Gay, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075141/
https://ncbi.nlm.nih.gov/pubmed/25165988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4596
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