Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals

In the early phase of bone damage, low concentrations of the cytokine tumor necrosis factor alpha (TNF-α) favor osteoblast differentiation. In contrast, chronic high doses of the same cytokine contribute to bone loss, demonstrating opposite effects depending on its concentration and on the time of e...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Daniele, Simona, Natali, Letizia, Giacomelli, Chiara, Campiglia, Pietro, Novellino, Ettore, Martini, Claudia, Trincavelli, Maria Letizia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376638/
https://ncbi.nlm.nih.gov/pubmed/28137910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00442-16
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