Alteration of the α(1)β(2)/α(2)β(1) subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice

BACKGROUND: Deer mice (Peromyscus maniculatus) that are native to high altitudes in the Rocky Mountains have evolved hemoglobins with an increased oxygen-binding affinity relative to those of lowland conspecifics. To elucidate the molecular mechanisms responsible for the evolved increase in hemoglob...

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Udgivet i:PLoS One
Main Authors: Inoguchi, Noriko, Mizuno, Nobuhiro, Baba, Seiki, Kumasaka, Takashi, Natarajan, Chandrasekhar, Storz, Jay F., Moriyama, Hideaki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376325/
https://ncbi.nlm.nih.gov/pubmed/28362841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174921
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