Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner

In light of the weak or absent neutralizing activity mediated by anti-V2 monoclonal antibodies (MAbs), we tested whether they can mediate Ab-dependent cellular phagocytosis (ADCP), which is an important element of anti-HIV-1 immunity. We tested six anti-V2 MAbs and compared them with 21 MAbs specifi...

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Vydáno v:J Virol
Hlavní autoři: Musich, Thomas, Li, Liuzhe, Liu, Lily, Zolla-Pazner, Susan, Robert-Guroff, Marjorie, Gorny, Miroslaw K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375680/
https://ncbi.nlm.nih.gov/pubmed/28122974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02325-16
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