Nonneutralizing HIV-1 gp41 Envelope Cluster II Human Monoclonal Antibodies Show Polyreactivity for Binding to Phospholipids and Protein Autoantigens

HIV-1 gp41 envelope antibodies, which are frequently induced in HIV-1-infected individuals, are predominantly nonneutralizing. The rare and difficult-to-induce neutralizing antibodies (2F5 and 4E10) that target gp41 membrane-proximal epitopes (MPER) are polyspecific and require lipid binding for HIV...

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Autors principals: Dennison, S. Moses, Anasti, Kara, Scearce, Richard M., Sutherland, Laura, Parks, Robert, Xia, Shi-Mao, Liao, Hua-Xin, Gorny, Miroslaw K., Zolla-Pazner, Susan, Haynes, Barton F., Alam, S. Munir
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2011
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020517/
https://ncbi.nlm.nih.gov/pubmed/21106741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01680-10
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