Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB

The type I interferon (IFN) response is part of the first-line defense against viral infection. To initiate replication, viruses have developed powerful evasion strategies to counteract host IFN responses. In the present study, we found that the Japanese encephalitis virus (JEV) NS5 protein could in...

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Publicado en:J Virol
Autores principales: Ye, Jing, Chen, Zheng, Li, Yunchuan, Zhao, Zikai, He, Wen, Zohaib, Ali, Song, Yunfeng, Deng, Chenglin, Zhang, Bo, Chen, Huanchun, Cao, Shengbo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375679/
https://ncbi.nlm.nih.gov/pubmed/28179530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00039-17
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