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Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus

Japanese encephalitis virus (JEV) is a flavivirus that threatens more than half of the world’s population. Vaccination can prevent the disease, but no specific antiviral drug is yet available for clinical therapy, and the death rate caused by JEV can reach as high as 60%. The C-terminus of non-struc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fang, Jin’e, Li, Huan, Kong, Dexin, Cao, Shengbo, Peng, Guiqing, Zhou, Rui, Chen, Huanchun, Song, Yunfeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041104/
https://ncbi.nlm.nih.gov/pubmed/27679979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34550
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