Ibrutinib inhibits pre-BCR(+) B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK

Targeting B-cell receptor (BCR) signaling is a successful therapeutic strategy in mature B-cell malignancies. Precursor BCR (pre-BCR) signaling, which is critical during normal B lymphopoiesis, also plays an important role in pre-BCR(+) B cell acute lymphoblastic leukemia (B-ALL). Here, we investiga...

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Publicat a:Blood
Autors principals: Kim, Ekaterina, Hurtz, Christian, Koehrer, Stefan, Wang, Zhiqiang, Balasubramanian, Sriram, Chang, Betty Y., Müschen, Markus, Davis, R. Eric, Burger, Jan A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2017
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374732/
https://ncbi.nlm.nih.gov/pubmed/28031181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-06-722900
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