Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing

Resistance-associated variant (RAV) is one of the most significant clinical challenges in treating HCV-infected patients with direct-acting antivirals (DAAs). We investigated the viral dynamics in patients receiving DAAs using third-generation sequencing technology. Among 283 patients with genotype-...

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Pubblicato in:Sci Rep
Autori principali: Takeda, Haruhiko, Ueda, Yoshihide, Inuzuka, Tadashi, Yamashita, Yukitaka, Osaki, Yukio, Nasu, Akihiro, Umeda, Makoto, Takemura, Ryo, Seno, Hiroshi, Sekine, Akihiro, Marusawa, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374541/
https://ncbi.nlm.nih.gov/pubmed/28361915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45605
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