Genetic Heterogeneity of Hepatitis C Virus in Association with Antiviral Therapy Determined by Ultra-Deep Sequencing

BACKGROUND AND AIMS: The hepatitis C virus (HCV) invariably shows wide heterogeneity in infected patients, referred to as a quasispecies population. Massive amounts of genetic information due to the abundance of HCV variants could be an obstacle to evaluate the viral genetic heterogeneity in detail....

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Hauptverfasser: Nasu, Akihiro, Marusawa, Hiroyuki, Ueda, Yoshihide, Nishijima, Norihiro, Takahashi, Ken, Osaki, Yukio, Yamashita, Yukitaka, Inokuma, Tetsuro, Tamada, Takashi, Fujiwara, Takeshi, Sato, Fumiaki, Shimizu, Kazuharu, Chiba, Tsutomu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178558/
https://ncbi.nlm.nih.gov/pubmed/21966381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024907
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