Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a severe and progressive neuronal loss leading to cognitive dysfunctions. Previous reports, based on the use of chemical inhibitors, have connected the stress kinase p38α to neuroinflammation, neuronal death and synaptic dysfu...

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Vydáno v:Sci Rep
Hlavní autoři: Colié, Sandra, Sarroca, Sara, Palenzuela, Rocío, Garcia, Idoia, Matheu, Ander, Corpas, Rubén, Dotti, Carlos G., Esteban, José A., Sanfeliu, Coral, Nebreda, Angel R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374488/
https://ncbi.nlm.nih.gov/pubmed/28361984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45306
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