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Alcohol drives S-nitrosylation and redox activation of protein phosphatase 1, causing bovine airway cilia dysfunction

Individuals with alcohol (ethanol)-use disorders are at increased risk for lung infections, in part, due to defective mucociliary clearance driven by motile cilia in the airways. We recently reported that isolated, demembranated bovine cilia (axonemes) are capable of producing nitric oxide ((∙)NO) w...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Price, Michael E., Pavlik, Jacqueline A., Liu, Miao, Ding, Shi-Jian, Wyatt, Todd A., Sisson, Joseph H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374300/
https://ncbi.nlm.nih.gov/pubmed/28062487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00513.2016
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