Promyelocytic extracellular chromatin exacerbates coagulation and fibrinolysis in acute promyelocytic leukemia

Despite routine treatment of unselected acute promyelocytic leukemia (APL) with all-trans-retinoic acid (ATRA), early death because of hemorrhage remains unacceptably common, and the mechanism underlying this complication remains elusive. We have recently demonstrated that APL cells undergo a novel...

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Veröffentlicht in:Blood
Hauptverfasser: Cao, Muhua, Li, Tao, He, Zhangxiu, Wang, Lixiu, Yang, Xiaoyan, Kou, Yan, Zou, Lili, Dong, Xue, Novakovic, Valerie A., Bi, Yayan, Kou, Junjie, Yu, Bo, Fang, Shaohong, Wang, Jinghua, Zhou, Jin, Shi, Jialan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374289/
https://ncbi.nlm.nih.gov/pubmed/28053193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-739334
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