Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia

Type 2 diabetes is associated with altered immune and hemostatic responses. We investigated the selective effects of hyperglycemia and hyperinsulinemia on innate immune, coagulation, and fibrinolytic responses during systemic inflammation. Twenty-four healthy humans were studied for 8 hours during c...

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Hlavní autoři: Stegenga, Michiel E., van der Crabben, Saskia N., Blümer, Regje M. E., Levi, Marcel, Meijers, Joost C. M., Serlie, Mireille J., Tanck, Michael W. T., Sauerwein, Hans P., van der Poll, Tom
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Hemostasis, Thrombosis, and Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435690/
https://ncbi.nlm.nih.gov/pubmed/18316629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-121723
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