Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia

Type 2 diabetes is associated with altered immune and hemostatic responses. We investigated the selective effects of hyperglycemia and hyperinsulinemia on innate immune, coagulation, and fibrinolytic responses during systemic inflammation. Twenty-four healthy humans were studied for 8 hours during c...

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Autori principali: Stegenga, Michiel E., van der Crabben, Saskia N., Blümer, Regje M. E., Levi, Marcel, Meijers, Joost C. M., Serlie, Mireille J., Tanck, Michael W. T., Sauerwein, Hans P., van der Poll, Tom
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Hemostasis, Thrombosis, and Vascular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435690/
https://ncbi.nlm.nih.gov/pubmed/18316629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-121723
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