Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia

Type 2 diabetes is associated with altered immune and hemostatic responses. We investigated the selective effects of hyperglycemia and hyperinsulinemia on innate immune, coagulation, and fibrinolytic responses during systemic inflammation. Twenty-four healthy humans were studied for 8 hours during c...

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Main Authors: Stegenga, Michiel E., van der Crabben, Saskia N., Blümer, Regje M. E., Levi, Marcel, Meijers, Joost C. M., Serlie, Mireille J., Tanck, Michael W. T., Sauerwein, Hans P., van der Poll, Tom
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2008
Teme:
Hemostasis, Thrombosis, and Vascular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435690/
https://ncbi.nlm.nih.gov/pubmed/18316629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-121723
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