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Protein unfolding under isometric tension – what force can integrins generate, and can it unfold FNIII domains?

Extracellular matrix fibrils of fibronectin (FN) are highly elastic, and are typically stretched three to four times their relaxed length. The mechanism of stretching has been controversial, in particular whether it involves tension-induced unfolding of FNIII domains. Recent studies have found that...

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Bibliografiske detaljer
Udgivet i:Curr Opin Struct Biol
Hovedforfatter: Erickson, Harold P.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374013/
https://ncbi.nlm.nih.gov/pubmed/28038331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2016.12.002
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