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Protein unfolding under isometric tension – what force can integrins generate, and can it unfold FNIII domains?
Extracellular matrix fibrils of fibronectin (FN) are highly elastic, and are typically stretched three to four times their relaxed length. The mechanism of stretching has been controversial, in particular whether it involves tension-induced unfolding of FNIII domains. Recent studies have found that...
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| Udgivet i: | Curr Opin Struct Biol |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5374013/ https://ncbi.nlm.nih.gov/pubmed/28038331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2016.12.002 |
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