ENDOGENOUSLY PRODUCED NONCLASSICAL VITAMIN D HYDROXY-METABOLITES ACT AS “BIASED” AGONISTS ON VDR AND INVERSE AGONISTS ON RORα AND RORγ

The classical pathway of vitamin D activation follows the sequence D3→25(OH)D3→1,25(OH)(2)D3 with the final product acting on the receptor for vitamin D (VDR). An alternative pathway can be started by the action of CYP11A1 on the side chain of D3, primarily producing 20(OH)D3, 22(OH)D3, 20,23(OH)(2)...

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Détails bibliographiques
Publié dans:J Steroid Biochem Mol Biol
Auteurs principaux: Slominski, Andrzej T., Kim, Tae-Kang, Hobrath, Judith V., Oak, Allen S.W., Tang, Edith K. Y., Tieu, Elaine W., Li, Wei, Tuckey, Robert C., Jetten, Anton M.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373926/
https://ncbi.nlm.nih.gov/pubmed/27693422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2016.09.024
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