T cells control the generation of nanomolar-affinity anti-glycan antibodies

Vaccines targeting glycan structures at the surface of pathogenic microbes must overcome the inherent T cell–independent nature of immune responses against glycans. Carbohydrate conjugate vaccines achieve this by coupling bacterial polysaccharides to a carrier protein that recruits heterologous CD4...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Polonskaya, Zinaida, Deng, Shenglou, Sarkar, Anita, Kain, Lisa, Comellas-Aragones, Marta, McKay, Craig S., Kaczanowska, Katarzyna, Holt, Marie, McBride, Ryan, Palomo, Valle, Self, Kevin M., Taylor, Seth, Irimia, Adriana, Mehta, Sanjay R., Dan, Jennifer M., Brigger, Matthew, Crotty, Shane, Schoenberger, Stephen P., Paulson, James C., Wilson, Ian A., Savage, Paul B., Finn, M.G., Teyton, Luc
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373877/
https://ncbi.nlm.nih.gov/pubmed/28287405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91192
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