Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

SIRT2 is a cytoplasmic sirtuin that plays a role in various cellular processes, including tumorigenesis, metabolism, and inflammation. Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis. Here, we have demonstrated that SIRT2 depletion results...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Yang, Xiaoyan, Park, Seong-Hoon, Chang, Hsiang-Chun, Shapiro, Jason S., Vassilopoulos, Athanassios, Sawicki, Konrad T., Chen, Chunlei, Shang, Meng, Burridge, Paul W., Epting, Conrad L., Wilsbacher, Lisa D., Jenkitkasemwong, Supak, Knutson, Mitchell, Gius, David, Ardehali, Hossein
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373873/
https://ncbi.nlm.nih.gov/pubmed/28287409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88574
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