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Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

SIRT2 is a cytoplasmic sirtuin that plays a role in various cellular processes, including tumorigenesis, metabolism, and inflammation. Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis. Here, we have demonstrated that SIRT2 depletion results...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Clin Invest
Main Authors: Yang, Xiaoyan, Park, Seong-Hoon, Chang, Hsiang-Chun, Shapiro, Jason S., Vassilopoulos, Athanassios, Sawicki, Konrad T., Chen, Chunlei, Shang, Meng, Burridge, Paul W., Epting, Conrad L., Wilsbacher, Lisa D., Jenkitkasemwong, Supak, Knutson, Mitchell, Gius, David, Ardehali, Hossein
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373873/
https://ncbi.nlm.nih.gov/pubmed/28287409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88574
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