Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

SIRT2 is a cytoplasmic sirtuin that plays a role in various cellular processes, including tumorigenesis, metabolism, and inflammation. Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis. Here, we have demonstrated that SIRT2 depletion results...

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Pubblicato in:J Clin Invest
Autori principali: Yang, Xiaoyan, Park, Seong-Hoon, Chang, Hsiang-Chun, Shapiro, Jason S., Vassilopoulos, Athanassios, Sawicki, Konrad T., Chen, Chunlei, Shang, Meng, Burridge, Paul W., Epting, Conrad L., Wilsbacher, Lisa D., Jenkitkasemwong, Supak, Knutson, Mitchell, Gius, David, Ardehali, Hossein
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373873/
https://ncbi.nlm.nih.gov/pubmed/28287409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88574
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