Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

SIRT2 is a cytoplasmic sirtuin that plays a role in various cellular processes, including tumorigenesis, metabolism, and inflammation. Since these processes require iron, we hypothesized that SIRT2 directly regulates cellular iron homeostasis. Here, we have demonstrated that SIRT2 depletion results...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Yang, Xiaoyan, Park, Seong-Hoon, Chang, Hsiang-Chun, Shapiro, Jason S., Vassilopoulos, Athanassios, Sawicki, Konrad T., Chen, Chunlei, Shang, Meng, Burridge, Paul W., Epting, Conrad L., Wilsbacher, Lisa D., Jenkitkasemwong, Supak, Knutson, Mitchell, Gius, David, Ardehali, Hossein
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373873/
https://ncbi.nlm.nih.gov/pubmed/28287409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88574
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