Isocitrate dehydrogenase mutations suppress STAT1 and CD8(+) T cell accumulation in gliomas

Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among the first genetic alterations observed during the development of lower-grade glioma (LGG). LGG-associated IDH mutations confer gain-of-function activity by converting α-ketoglutarate to the oncometabolite R-2-hydroxyglutarate (2...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kohanbash, Gary, Carrera, Diego A., Shrivastav, Shruti, Ahn, Brian J., Jahan, Naznin, Mazor, Tali, Chheda, Zinal S., Downey, Kira M., Watchmaker, Payal B., Beppler, Casey, Warta, Rolf, Amankulor, Nduka A., Herold-Mende, Christel, Costello, Joseph F., Okada, Hideho
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373859/
https://ncbi.nlm.nih.gov/pubmed/28319047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90644
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