SMARCA4 ATPase mutations disrupt direct eviction of PRC1 from chromatin

Trithorax-group genes and mammalian homologues, including BAF (mSWI/SNF) complexes, have been known for nearly 30 years to oppose Polycomb repressive activity(1–5). This opposition underlies the tumor-suppression role of BAF(3,5–7) and is expected to contribute to neurodevelopmental disorders, as ev...

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Bibliographic Details
Published in:Nat Genet
Main Authors: Stanton, Benjamin Z., Hodges, Courtney, Calarco, Joseph P., Braun, Simon M. G., Ku, Wai Lim, Kadoch, Cigall, Zhao, Keji, Crabtree, Gerald R.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373480/
https://ncbi.nlm.nih.gov/pubmed/27941795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3735
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