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SMARCA4 ATPase mutations disrupt direct eviction of PRC1 from chromatin
Trithorax-group genes and mammalian homologues, including BAF (mSWI/SNF) complexes, have been known for nearly 30 years to oppose Polycomb repressive activity(1–5). This opposition underlies the tumor-suppression role of BAF(3,5–7) and is expected to contribute to neurodevelopmental disorders, as ev...
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| Izdano u: | Nat Genet |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5373480/ https://ncbi.nlm.nih.gov/pubmed/27941795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3735 |
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