Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho

αKlotho (αKL) regulates mineral metabolism, and diseases associated with αKL deficiency are characterized by hyperphosphatemia and vascular calcification (VC). αKL is expressed as a membrane-bound protein (mKL) and recognized as the coreceptor for fibroblast growth factor-23 (FGF23) and a circulatin...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Autores principales: Hum, Julia M., O’Bryan, Linda M., Tatiparthi, Arun K., Cass, Taryn A., Clinkenbeard, Erica L., Cramer, Martin S., Bhaskaran, Manoj, Johnson, Robert L., Wilson, Jonathan M., Smith, Rosamund C., White, Kenneth E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2017
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373441/
https://ncbi.nlm.nih.gov/pubmed/27837149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015111266
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