Circulating αKlotho influences phosphate handling by controlling FGF23 production

The FGF23 coreceptor αKlotho (αKL) is expressed as a membrane-bound protein (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate intracellular signaling. It also circulates as an endoproteolytic cleavage product of mKL (cKL). Previously, a patient with increased plasma cKL a...

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Detalhes bibliográficos
Main Authors: Smith, Rosamund C., O’Bryan, Linda M., Farrow, Emily G., Summers, Lelia J., Clinkenbeard, Erica L., Roberts, Jessica L., Cass, Taryn A., Saha, Joy, Broderick, Carol, Ma, Y. Linda, Zeng, Qing Qiang, Kharitonenkov, Alexei, Wilson, Jonathan M., Guo, Qianxu, Sun, Haijun, Allen, Matthew R., Burr, David B., Breyer, Matthew D., White, Kenneth E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533557/
https://ncbi.nlm.nih.gov/pubmed/23187128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64986
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