Circulating αKlotho influences phosphate handling by controlling FGF23 production

The FGF23 coreceptor αKlotho (αKL) is expressed as a membrane-bound protein (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate intracellular signaling. It also circulates as an endoproteolytic cleavage product of mKL (cKL). Previously, a patient with increased plasma cKL a...

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Bibliografiske detaljer
Main Authors: Smith, Rosamund C., O’Bryan, Linda M., Farrow, Emily G., Summers, Lelia J., Clinkenbeard, Erica L., Roberts, Jessica L., Cass, Taryn A., Saha, Joy, Broderick, Carol, Ma, Y. Linda, Zeng, Qing Qiang, Kharitonenkov, Alexei, Wilson, Jonathan M., Guo, Qianxu, Sun, Haijun, Allen, Matthew R., Burr, David B., Breyer, Matthew D., White, Kenneth E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533557/
https://ncbi.nlm.nih.gov/pubmed/23187128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64986
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