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Hysteresis of KcsA potassium channel's activation– deactivation gating is caused by structural changes at the channel’s selectivity filter

Mode-shift or hysteresis has been reported in ion channels. Voltage-shift for gating currents is well documented for voltage-gated cation channels (VGCC), and it is considered a voltage-sensing domain's (VSD) intrinsic property. However, uncoupling the Shaker K(+) channel’s pore domain (PD) fro...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Tilegenova, Cholpon, Cortes, D. Marien, Cuello, Luis G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373385/
https://ncbi.nlm.nih.gov/pubmed/28265056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618101114
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