Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis

Nonalcoholic fatty liver disease (NAFLD) is characterized by simple hepatic steatosis (SS), nonalcoholic steatohepatitis (NASH), hepatic fibrosis, and cirrhosis. Dysregulated fatty acid metabolism in the liver plays a critical role in the pathogenesis of NAFLD. Cytochrome P450 omega-hydroxylase 4A14...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Zhang, Xiaoyan, Li, Sha, Zhou, Yunfeng, Su, Wen, Ruan, Xiongzhong, Wang, Bing, Zheng, Feng, Warner, Margaret, Gustafsson, Jan-Åke, Guan, Youfei
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373383/
https://ncbi.nlm.nih.gov/pubmed/28270609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700172114
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