Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis

Nonalcoholic fatty liver disease (NAFLD) is characterized by simple hepatic steatosis (SS), nonalcoholic steatohepatitis (NASH), hepatic fibrosis, and cirrhosis. Dysregulated fatty acid metabolism in the liver plays a critical role in the pathogenesis of NAFLD. Cytochrome P450 omega-hydroxylase 4A14...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhang, Xiaoyan, Li, Sha, Zhou, Yunfeng, Su, Wen, Ruan, Xiongzhong, Wang, Bing, Zheng, Feng, Warner, Margaret, Gustafsson, Jan-Åke, Guan, Youfei
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373383/
https://ncbi.nlm.nih.gov/pubmed/28270609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700172114
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