Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

In its soluble form, the extracellular matrix proteoglycan biglycan triggers the synthesis of the macrophage chemoattractants, chemokine (C-C motif) ligand CCL2 and CCL5 through selective utilization of Toll-like receptors (TLRs) and their adaptor molecules. However, the respective downstream signal...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Hsieh, Louise Tzung-Harn, Nastase, Madalina-Viviana, Roedig, Heiko, Zeng-Brouwers, Jinyang, Poluzzi, Chiara, Schwalm, Stephanie, Fork, Christian, Tredup, Claudia, Brandes, Ralf P., Wygrecka, Malgorzata, Huwiler, Andrea, Pfeilschifter, Josef, Schaefer, Liliana
Format: Artigo
Language:Inglês
Published: MDPI 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5372611/
https://ncbi.nlm.nih.gov/pubmed/28282921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18030595
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