Development of a facile antibody–drug conjugate platform for increased stability and homogeneity

Despite the advances in the design of antibody–drug conjugates (ADCs), the search is still ongoing for novel approaches that lead to increased stability and homogeneity of the ADCs. We report, for the first time, an ADC platform technology using a platinum(ii)-based linker that can re-bridge the int...

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Publicado en:Chem Sci
Autores principales: Gupta, Nimish, Kancharla, Johny, Kaushik, Shelly, Ansari, Aasif, Hossain, Samad, Goyal, Ravinder, Pandey, Manoj, Sivaccumar, Jwala, Hussain, Sazid, Sarkar, Arindam, Sengupta, Aniruddha, Mandal, Swadhin K., Roy, Monideepa, Sengupta, Shiladitya
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369337/
https://ncbi.nlm.nih.gov/pubmed/28451344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc05149a
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