Development of a facile antibody–drug conjugate platform for increased stability and homogeneity

Despite the advances in the design of antibody–drug conjugates (ADCs), the search is still ongoing for novel approaches that lead to increased stability and homogeneity of the ADCs. We report, for the first time, an ADC platform technology using a platinum(ii)-based linker that can re-bridge the int...

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Gepubliceerd in:Chem Sci
Hoofdauteurs: Gupta, Nimish, Kancharla, Johny, Kaushik, Shelly, Ansari, Aasif, Hossain, Samad, Goyal, Ravinder, Pandey, Manoj, Sivaccumar, Jwala, Hussain, Sazid, Sarkar, Arindam, Sengupta, Aniruddha, Mandal, Swadhin K., Roy, Monideepa, Sengupta, Shiladitya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2017
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369337/
https://ncbi.nlm.nih.gov/pubmed/28451344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc05149a
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