LKB1 and AMPK regulate synaptic remodeling in old age

Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of i...

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Bibliographic Details
Published in:Nat Neurosci
Main Authors: Samuel, Melanie A, Voinescu, P Emanuela, Lilley, Brendan N, de Cabo, Rafa, Foretz, Marc, Viollet, Benoit, Pawlyk, Basil, Sandberg, Michael A, Vavvas, Demetrios G, Sanes, Joshua R
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369022/
https://ncbi.nlm.nih.gov/pubmed/25086610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3772
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