The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass

The nicotinic receptor α7nAchR reportedly regulates vagal nerve targets in brain and cardiac tissue. Here we show that nAchR7(−/−) mice exhibit increased bone mass due to decreased osteoclast formation, accompanied by elevated osteoprotegerin/RANKL ratios in serum. Vagotomy in wild-type mice also si...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Mito, Kazuaki, Sato, Yuiko, Kobayashi, Tami, Miyamoto, Kana, Nitta, Eriko, Iwama, Atsushi, Matsumoto, Morio, Nakamura, Masaya, Sato, Kazuki, Miyamoto, Takeshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368561/
https://ncbi.nlm.nih.gov/pubmed/28349965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45597
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