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The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass
The nicotinic receptor α7nAchR reportedly regulates vagal nerve targets in brain and cardiac tissue. Here we show that nAchR7(−/−) mice exhibit increased bone mass due to decreased osteoclast formation, accompanied by elevated osteoprotegerin/RANKL ratios in serum. Vagotomy in wild-type mice also si...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5368561/ https://ncbi.nlm.nih.gov/pubmed/28349965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45597 |
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