The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass

The nicotinic receptor α7nAchR reportedly regulates vagal nerve targets in brain and cardiac tissue. Here we show that nAchR7(−/−) mice exhibit increased bone mass due to decreased osteoclast formation, accompanied by elevated osteoprotegerin/RANKL ratios in serum. Vagotomy in wild-type mice also si...

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Udgivet i:Sci Rep
Main Authors: Mito, Kazuaki, Sato, Yuiko, Kobayashi, Tami, Miyamoto, Kana, Nitta, Eriko, Iwama, Atsushi, Matsumoto, Morio, Nakamura, Masaya, Sato, Kazuki, Miyamoto, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368561/
https://ncbi.nlm.nih.gov/pubmed/28349965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45597
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