Viral Vector Malaria Vaccines Induce High-Level T Cell and Antibody Responses in West African Children and Infants

Heterologous prime-boosting with viral vectors encoding the pre-erythrocytic antigen thrombospondin-related adhesion protein fused to a multiple epitope string (ME-TRAP) induces CD8(+) T cell-mediated immunity to malaria sporozoite challenge in European malaria-naive and Kenyan semi-immune adults. T...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Bliss, Carly M., Drammeh, Abdoulie, Bowyer, Georgina, Sanou, Guillaume S., Jagne, Ya Jankey, Ouedraogo, Oumarou, Edwards, Nick J., Tarama, Casimir, Ouedraogo, Nicolas, Ouedraogo, Mireille, Njie-Jobe, Jainaba, Diarra, Amidou, Afolabi, Muhammed O., Tiono, Alfred B., Yaro, Jean Baptiste, Adetifa, Uche J., Hodgson, Susanne H., Anagnostou, Nicholas A., Roberts, Rachel, Duncan, Christopher J.A., Cortese, Riccardo, Viebig, Nicola K., Leroy, Odile, Lawrie, Alison M., Flanagan, Katie L., Kampmann, Beate, Imoukhuede, Egeruan B., Sirima, Sodiomon B., Bojang, Kalifa, Hill, Adrian V.S., Nébié, Issa, Ewer, Katie J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368405/
https://ncbi.nlm.nih.gov/pubmed/28153101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.003
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