Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis()()

BACKGROUND: Irinotecan (IRI) is an integral part of colorectal cancer (CRC) therapy, but response rates are unsatisfactory and resistance mechanisms are still insufficiently understood. As fibroblast growth factor receptor 3 (FGFR3) mediates essential survival signals in CRC, it is a candidate gene...

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Veröffentlicht in:Transl Oncol
Hauptverfasser: Erdem, Zeynep N., Schwarz, Stefanie, Drev, Daniel, Heinzle, Christine, Reti, Andrea, Heffeter, Petra, Hudec, Xenia, Holzmann, Klaus, Grasl-Kraupp, Bettina, Berger, Walter, Grusch, Michael, Marian, Brigitte
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2017
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367848/
https://ncbi.nlm.nih.gov/pubmed/28340475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2017.02.004
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