Fibroblast Growth Factor Receptors as Therapeutic Targets in Human Melanoma: Synergism with BRAF Inhibition

Cutaneous melanoma is a tumor with rising incidence and a very poor prognosis at the disseminated stage. Melanomas are characterized by frequent mutations in BRAF and also by overexpression of fibroblast growth factor 2 (FGF2), offering opportunities for therapeutic intervention. We investigated inh...

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Autori principali: Metzner, Thomas, Bedeir, Alexandra, Held, Gerlinde, Peter-Vörösmarty, Barbara, Ghassemi, Sara, Heinzle, Christine, Spiegl-Kreinecker, Sabine, Marian, Brigitte, Holzmann, Klaus, Grasl-Kraupp, Bettina, Pirker, Christine, Micksche, Michael, Berger, Walter, Heffeter, Petra, Grusch, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383623/
https://ncbi.nlm.nih.gov/pubmed/21753785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2011.177
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