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Patient-specific modeling of individual sickle cell behavior under transient hypoxia
Sickle cell disease (SCD) is a highly complex genetic blood disorder in which red blood cells (RBC) exhibit heterogeneous morphology changes and decreased deformability. We employ a kinetic model for cell morphological sickling that invokes parameters derived from patient-specific data. This model i...
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| Pubblicato in: | PLoS Comput Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5367819/ https://ncbi.nlm.nih.gov/pubmed/28288152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005426 |
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