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Immunostimulatory Effects of Melphalan and Usefulness in Adoptive Cell Therapy with Antitumor CD4+ T Cells

The alkylating agent melphalan is used in the treatment of hematological malignancies, especially multiple myeloma. In the past, the usefulness of melphalan has been solely attributed to its cytotoxicity on fast-growing cancerous cells. Although the immunomodulatory effects of melphalan were suggest...

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Vydáno v:Crit Rev Immunol
Hlavní autoři: Kuczma, Michal, Ding, Zhi-Chun, Zhou, Gang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367467/
https://ncbi.nlm.nih.gov/pubmed/27910767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1615/CritRevImmunol.2016017507
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