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Immunostimulatory Effects of Melphalan and Usefulness in Adoptive Cell Therapy with Antitumor CD4+ T Cells

The alkylating agent melphalan is used in the treatment of hematological malignancies, especially multiple myeloma. In the past, the usefulness of melphalan has been solely attributed to its cytotoxicity on fast-growing cancerous cells. Although the immunomodulatory effects of melphalan were suggest...

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Detalhes bibliográficos
Publicado no:Crit Rev Immunol
Main Authors: Kuczma, Michal, Ding, Zhi-Chun, Zhou, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367467/
https://ncbi.nlm.nih.gov/pubmed/27910767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1615/CritRevImmunol.2016017507
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