NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

BACKGROUND: NADPH oxidase (NOX2) is an enzyme system that generates reactive oxygen species (ROS) in microglia and macrophages. Excessive ROS production is linked with neuroinflammation and chronic neurodegeneration following traumatic brain injury (TBI). Redox signaling regulates macrophage/microgl...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Barrett, James P., Henry, Rebecca J., Villapol, Sonia, Stoica, Bogdan A., Kumar, Alok, Burns, Mark P., Faden, Alan I., Loane, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366128/
https://ncbi.nlm.nih.gov/pubmed/28340575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0843-4
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