NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

BACKGROUND: NADPH oxidase (NOX2) is an enzyme system that generates reactive oxygen species (ROS) in microglia and macrophages. Excessive ROS production is linked with neuroinflammation and chronic neurodegeneration following traumatic brain injury (TBI). Redox signaling regulates macrophage/microgl...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Barrett, James P., Henry, Rebecca J., Villapol, Sonia, Stoica, Bogdan A., Kumar, Alok, Burns, Mark P., Faden, Alan I., Loane, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366128/
https://ncbi.nlm.nih.gov/pubmed/28340575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0843-4
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