Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics

Unique bicyclic octosyl uronic acid nucleosides include ezomycin, malayamycin, and octosyl acid (OA). They are structurally characterized by OA, an unusual 8-carbon furanosyl nucleoside core proposed to be the precursor to polyoxin and nikkomycin. Despite the well-known bioactivity of these nucleosi...

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Publicado en:Chem Sci
Autores principales: He, Nisha, Wu, Pan, Lei, Yongxing, Xu, Baofu, Zhu, Xiaochen, Xu, Gudan, Gao, Yaojie, Qi, Jianzhao, Deng, Zixin, Tang, Gongli, Chen, Wenqing, Xiao, Youli
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365060/
https://ncbi.nlm.nih.gov/pubmed/28451191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc01826b
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