Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model*

OBJECTIVE: While type 1 programmed cell death (apoptosis) of T cells leads to immunosuppression in sepsis, a crosstalk between apoptosis and autophagy (type 2 programmed cell death) has not been shown. The aim of this study is to elucidate the details of the interaction between autophagy and immunos...

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Detalhes bibliográficos
Publicado no:Crit Care Med
Main Authors: Oami, Takehiko, Watanabe, Eizo, Hatano, Masahiko, Sunahara, Satoshi, Fujimura, Lisa, Sakamoto, Akemi, Ito, Chizuru, Toshimori, Kiyotaka, Oda, Shigeto
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2017
Assuntos:
Online Laboratory Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364514/
https://ncbi.nlm.nih.gov/pubmed/27618275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000002016
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