Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). Hence, reducing adipose tissue lipolysis to diminish the mobilization of FAs and lower their respective pl...

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Vydáno v:Nat Commun
Hlavní autoři: Schweiger, Martina, Romauch, Matthias, Schreiber, Renate, Grabner, Gernot F., Hütter, Sabrina, Kotzbeck, Petra, Benedikt, Pia, Eichmann, Thomas O., Yamada, Sohsuke, Knittelfelder, Oskar, Diwoky, Clemens, Doler, Carina, Mayer, Nicole, De Cecco, Werner, Breinbauer, Rolf, Zimmermann, Robert, Zechner, Rudolf
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364409/
https://ncbi.nlm.nih.gov/pubmed/28327588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14859
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