Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, is indispensable for normal cerebellar development. Genetic inactivation of...

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Publicat a:Nat Commun
Autors principals: Feng, Weijun, Kawauchi, Daisuke, Körkel-Qu, Huiqin, Deng, Huan, Serger, Elisabeth, Sieber, Laura, Lieberman, Jenna Ariel, Jimeno-González, Silvia, Lambo, Sander, Hanna, Bola S., Harim, Yassin, Jansen, Malin, Neuerburg, Anna, Friesen, Olga, Zuckermann, Marc, Rajendran, Vijayanad, Gronych, Jan, Ayrault, Olivier, Korshunov, Andrey, Jones, David T. W., Kool, Marcel, Northcott, Paul A., Lichter, Peter, Cortés-Ledesma, Felipe, Pfister, Stefan M., Liu, Hai-Kun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364396/
https://ncbi.nlm.nih.gov/pubmed/28317875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14758
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