Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, is indispensable for normal cerebellar development. Genetic inactivation of...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Feng, Weijun, Kawauchi, Daisuke, Körkel-Qu, Huiqin, Deng, Huan, Serger, Elisabeth, Sieber, Laura, Lieberman, Jenna Ariel, Jimeno-González, Silvia, Lambo, Sander, Hanna, Bola S., Harim, Yassin, Jansen, Malin, Neuerburg, Anna, Friesen, Olga, Zuckermann, Marc, Rajendran, Vijayanad, Gronych, Jan, Ayrault, Olivier, Korshunov, Andrey, Jones, David T. W., Kool, Marcel, Northcott, Paul A., Lichter, Peter, Cortés-Ledesma, Felipe, Pfister, Stefan M., Liu, Hai-Kun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364396/
https://ncbi.nlm.nih.gov/pubmed/28317875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14758
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